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Call: 281-497-2850

Robert G. Parker, DPM, FACFAS, FASPS, PA
14441 Memorial Drive, Suite 16, Houston, TX 77079

Prescription Medications Used for Pain caused by Neuropathy

Our goal at Neuropathy Care Center of Houston is to resolve your neuropathy either by surgical decompression of “choked nerves” or non-surgical treatments to reduce your dependency on prescription medications. For those patients who cannot have the new decompression and for those who, for medical reasons, cannot have prescription medications, we have Robotic Head MLS and MicroLight Cold Lasers, CET or Combination Electromagnetic Therapy, Neurogliding which have, in our experience, been very successful for conservative management of neuropathic pain.

 Neuropathy treatment options in Houston, TX.

After proper diagnosis of Neuropathy, we can then begin a treatment plan to get your neuropathic pain under control. A painful nerve problem requires a unique approach, as it is one of the most difficult and “nagging” types of pain that here is control and you want the best yet safest medication or therapy possible. Some are helped with nonprescription neutriceuticals where you might be diagnosed with a nutritional deficiency in vitamins, enzymes, proteins or minerals.

There are solutions and proper therapies to help feel normal once again, whatever the cause and location of pain might be.

Our discussion today is on a few prescription pain relievers.

Prescription Medications for Nerve Pain

There is a limited number of groups of prescription medications used that might help you with your particular nerve pain. For example, tricyclic antidepressants are, often, the first choice of medication when treating neuropathic pain. Antidepressants and Anticonvulsants both are powerful drugs in helping this disease.


Two different types of antidepressants which are recommended by nerve pain specialists are:

◦       Tricyclic antidepressants – Decades ago, these were extensively used for treating depression, however, now this drug class is used more for controlling nerve pain. Tricyclic drugs may develop side effects such as upset stomach, constipation, dizziness, and blurred vision. You especially don’t want to take this if you have cardiac problems.

Antidepressants used to treat neuropathy.

◦       Serotonin and Norepinephrine Reuptake Inhibitors – or SNRIs-These are newer than the tricyclic antidepressants. They are safer to use, and have fewer side effects than tricyclics, especially for the elderly or people with cardiac problems, as mentioned above. Tricyclics may be better with the immediate nerve pain than SNRIs.

How Serotonin inhibits reuptake.

What we do know and have personally experienced with our patients that come to us after months and years of neuropathic pain, is that chronic pain can cause depression in some individuals. Studies have suggested this as well and for this reason and the fact that nerve pain can be severe, anti-depressants can be used for both nerve pain and depression. While the antidepressants are improving the mood, they are also helping to reduce or get rid of the nerve pain.

Pain Medications for Neuropathy

Some patients may not want to take antidepressants when they are prescribed for their nerve pain due to concern it may be perceived that the nerve pain is mental and not physical. This is generally not true, because antidepressants work on both problems since they coincide with each other. There is such a condition of centralized pain where nothing local will help the pain. Phantom limb pain where a person may experience pain the foot of the very limb that has been amputated is that sort of pain that is truly now centered in the brain.

Here are some other prescription medications for nerve pain.

◦       Prescription Pain MedicationOpioids. Of course, pain medication can be as helpful as antidepressants or anticonvulsants when treating neuropathy. These should only be considered when the condition is severe. Narcotics work much faster than most other pain relievers but because of the danger of substance abuse and the risk of addiction, we only prescribe these as a last resort. In other words, when other medications do not work. Opioids/pain medications can cause stomach pain, constipation, and drowsiness.

Prescription NSAIDs for neuropathy pain.

◦       NSAIDs (nonsteroidal anti-inflammatory drugs)- These drugs typically work at the local tissues, where there is inflammation and don’t have a strong enough pain relief as do other pain medicines. They may, however, be a good adjunct with other medications.

◦       Compounded Transdermal Prescription Medications- may be very effective in relieving localized pain with little or no side effects besides minor skin irritations. This is a topical skin pain medication – another kind of pain killer where the application can deliver 4,6, or 8 different medicines transdermally (applied directly to the painful areas through the skin) with special gels or creams that help to transport them. One such common pain reliever is the lidocaine patch.

Lidocaine patch for neuropathy pain.

◦       Mixture of both types of drugs – Combining some medications may give better results. In the case of anticonvulsants and antidepressants, when combined, they may work better on nerve pain than when taken separately.


One of the top neuropathy specialists in Houston is Dr. Robert G. Parker at Neuropathy Care Center of Houston. With over three decades experience in successfully treating neuropathy both conservatively and operatively, Dr. Parker is typically able to successfully relieve neuropathic pain and disability. Treatment options include prescription medications, laser treatment, stem cell injections, topical pain creams, nutritional supplements, and the Dellon Decompression surgery. Dr. Parker has treated thousands of patients with decompression of the fibro-osseous tunnels since he was trained by John’s Hopkins’ A. Lee Dellon, MD in this specialized area of nerve surgery.

Most insurances are accepted at the practice for the Neuropathy Care Center of Houston. Call 281-497-2850 for more information and scheduling with Dr. Robert Parker- a podiatrist Houston trusts for neuropathy treatment!